我们的网站为什么显示成这样?

可能因为您的浏览器不支持样式,您可以更新您的浏览器到最新版本,以获取对此功能的支持,访问下面的网站,获取关于浏览器的信息:

|本期目录/Table of Contents|

非梗阻性无精子症患者细针抽吸取精失败风险预测模型(PDF)

《现代预防医学》[ISSN:1003-8507/CN:51-1365/R]

期数:
2019年12期
页码:
2113-2116
栏目:
流行病与统计方法
出版日期:
2019-06-23

文章信息/Info

Title:
Risk prediction model for fine needle aspiration failure in patients with non-obstructive azoospermia
作者:
易晓巍1伯贞艳1蒋小辉2马越1
1.四川大学华西公共卫生学院/四川大学华西第四医院,四川 成都 610041;
2.四川大学华西第二附属医院,四川 成都 610041
Author(s):
YI Xiao-wei* BO Zhen-yan JIANG Xiao-hui MA Yue
*West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, China
关键词:
非梗阻性无精子症细针抽吸风险预测模型
Keywords:
Non-obstructive azoospermia Fine needle aspiration Risk prediction model
分类号:
R181.2
DOI:
-
文献标识码:
A
摘要:
目的 利用非梗阻性无精子症(NOA)患者基本情况和临床指标预测采用细针抽吸(FNA)技术取精失败风险,根据预测结果为指导临床选择NOA患者取精方式提供参考依据。方法 收集334例采用FNA取精的NOA患者的基本信息和临床指标,单因素分析初步筛选潜在预测因子,构建多重logistic回归风险预测模型,结合逐步向前法和临床可解释性选择最优预测模型,以受试者工作特征曲线(ROC)下面积(AUC)评价最优模型预测能力,采用bootstrap获得校正过拟合后的AUC。结果 最优风险预测模型中解释变量包括年龄、睾丸体积和卵泡刺激素,其中OR值和95%CI分别为:年龄(≥35岁)0.217(0.103,0.457),卵泡刺激素1.127(1.081,1.175),睾丸体积(12~14 ml)0.576(0.276,1.200),睾丸体积(≥15 ml)0.253(0.122,0.525)。最优风险预测模型预测能力(确切AUC)为0.8191。结论 年龄、睾丸体积、卵泡刺激素是影响NOA患者采用FNA取精失败的危险因素,建立的最优风险预测模型具有良好的预测能力,可为临床中指导NOA患者采用FNA技术取精提供重要参考。
Abstract:
Objective To use the basic conditions and clinical indicators of patients with non-obstructive azoospermia (NOA) to predict the risk of failure by fine needle aspiration (FNA) technique, in order to guide the clinical selection. Methods The basic information and clinical indicators of 334 cases of NOA patients who received FNA were collected. Univariate analysis was used to screen the potential predictors, with multiple Logistic regression risk prediction model was built.The predictive capacity of the optimal model was evaluated using ROC analysis with bootstrap correction considering overfitting. Results The explanatory variables in the optimal risk prediction model included age(over 35 years), testicular volume and follicle stimulating hormone (FSH). The OR value and 95%CI of age (greater than or equal to 35 years)/FSH/ testicular volume (12-14 ml)/ testicular volume (greater than or equal to 15 ml) were 0.217(0.103,0.457), 1.127(1.081,1.175), 0.576 (0.276,1.200), 0.253 (0.122,0.525). The prediction ability of the optimal risk prediction mode (AUC) was 0.8191. Conclusion Age, testicular volume and follicle stimulating hormone are risk factors for failure of FNA semen extraction in NOA patients. The optimal risk prediction model has good predictive ability, which can provide important reference for giving proper recommendations of TESA to NOA patients.

参考文献/References

-

备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(81803332);国家自然科学基金项目(81872713);四川省科技厅重点研发项目(2018SZ0144、2018SZ0284);成都市技术创新研发项目(2018 - YF05 - 01265 - SN);四川大学专职博士后研发基金项目(2018 SCU12012)资助
作者简介:易晓巍(1994 - ),女,硕士在读,研究方向:流行病学与卫生统计学
通讯作者:马越,E-mail: gordonrozen@qq.com
更新日期/Last Update: 2019-06-25