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恶性孤立性肺结节危险因素的meta分析(PDF)

《现代预防医学》[ISSN:1003-8507/CN:51-1365/R]

期数:
2019年15期
页码:
2860-2864
栏目:
疾病预防控制
出版日期:
2019-08-15

文章信息/Info

Title:
Risk factors for malignant solitary pulmonary nodule:a meta-analysis
作者:
满君1张晓梅2于小林1刘彧杉1闫宏1崔晋伟1
1.北京中医药大学,北京 100029;
2.北京中医药大学东方医院,北京 100078
Author(s):
MAN Jun*ZHANG Xiao-meiYU Xiao-linLIU Yu-shanYAN HongCUI Jin-wei
*Beijing University of Traditional Chinese Medicine,Beijing 100029,China
关键词:
恶性孤立性肺结节危险因素病例对照研究meta分析
Keywords:
Malignant solitary pulmonary noduleRisk factorCase-control studyMeta-analysis
分类号:
R181.2+3
DOI:
-
文献标识码:
A
摘要:
目的 探讨中国人群恶性孤立性肺结节相关因素。方法 检索Pubmed、Embase、CNKI、WanFang Data和VIP数据库从建库至2018年9月所有关于恶性孤立性肺结节危险因素的病例对照研究,病例组为恶性肺结节组,对照组为良性肺结节组,由2名研究者盲法进行文献筛选、资料提取和质量评价,应用Stata15.0进行meta分析。结果 共纳入15篇文献,病例组2977例,对照组1501例,meta结果涉及12个危险因素,分别为高龄(OR=1.08,95%CI:1.05~1.10)、结节直径较大(OR=1.50,95%CI:1.29~1.74)、出现分叶征(OR=3.67,95%CI:2.87~4.70)、出现胸膜凹陷征(OR=2.63,95%CI:1.59~4.35)、出现毛刺征(OR=4.36,95%CI:3.03~6.27)、边界不清(OR=3.45,95%CI:2.16~5.50)、出现空泡征(OR=3.51,95%CI:1.86~6.63)、单纯磨玻璃结节(OR=18.14,95%CI:5.86~56.09)、出现血管穿行征(OR=4.75,95%CI:1.80~12.54)、既往肿瘤史(OR=3.64,95%CI:1.73~7.63)、淋巴结肿大(OR=3.26,95%CI:1.69~6.29)、肿瘤家族史(OR=3.17,95%CI:1.73~5.80),钙化(OR=0.29,95%CI:0.20~0.42)、边界清楚(OR=0.22,95%CI:0.14~0.35)更趋于良性结节。结论 依据胸CT征象和患者一般情况,可帮助识别肺结节的良恶性。
Abstract:
Objective To investigate the factors related to a malignant solitary pulmonary nodule in the Chinese population.Methods All case-control literature about risk factors for malignant isolated pulmonary nodule were retrieved from Pubmed,Embase,CNKI,Wan Fang Data and VIP database from the establishment of a database to September 2018.The case group in these studies was malignant pulmonary nodule,and the control group was benign pulmonary nodule.Literature screening,data extraction and quality evaluation were carried out by two researchers using the blind method,and Stata 15.0 software was used to analyze.Results 15 literatures,2977 cases in the case group and 1501 cases in the control group were included.Meta results involved 12 risk factors,including high age(OR=1.08,95%CI:1.05~1.10),long diameter(OR=1.50,95%CI:1.29~1.74),with lobulation(OR=3.67,95%CI:2.87~4.70),with traction of pleural(OR=2.63,95%CI:1.59~4.35),with glitches(OR=4.36,95%CI:3.03~6.27),rough edge(OR=4.36,95%CI:3.03~6.27),nodule with an area of air(OR=3.51,95%CI:1.86~6.63),pure ground glass nodule(OR=18.14,95%CI:5.86~56.09),with vascular breakthrough sign(OR=4.75,95%CI:1.80~12.54),history of tumor(OR=3.64,95%CI:1.73~7.63),lymphadenectasis(OR=3.26,95%CI:1.69~6.29),family history of tumor(OR=3.17,95%CI:1.73~5.80).The two protective factors were calcification(OR=0.29,95%CI:0.20~0.42),clear boundary(OR=0.22,95%CI:0.14~0.35).Conclusion The signs of chest CT and the general situation of the patient can help to identify the benign and malignant pulmonary nodules.

参考文献/References

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备注/Memo

备注/Memo:
作者简介:满君(1988-),女,在读博士,研究方向:中医药治疗呼吸系统疾病
通讯作者:张晓梅,E-mail:zhangxim6767@sina.com
更新日期/Last Update: 2019-08-16