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2型糖尿病与抵抗素基因多态性关系的研究(PDF)

《现代预防医学》[ISSN:1003-8507/CN:51-1365/R]

期数:
2022年14期
页码:
2523-2526
栏目:
流行病与统计方法
出版日期:
2022-07-30

文章信息/Info

Title:
Study on the relationship between type 2 diabetes and resistin gene polymorphism
作者:
周琳1罗玮2
1.青海大学研究生院,青海 西宁 810016;
2.青海省人民医院内分泌科,青海 西宁810001
Author(s):
ZHOU Lin* LUO Wei
*Graduate School of Qinghai University, Xining, Qinghai 810016, China
关键词:
抵抗素基因多态性胰岛素抵抗代谢综合征2型糖尿病
Keywords:
Resistin gene polymorphism Insulin resistance Metabolic syndrome Type 2 diabetes
分类号:
R587.1
DOI:
10.20043/j.cnki.MPM.202112589
文献标识码:
A
摘要:
2型糖尿病(diabetes mellitus type 2,T2DM)是一种复杂的代谢性疾病,是21世纪威胁人类健康的主要疾病之一,可导致严重的发病率和死亡率,是以血糖升高,碳水化合物、蛋白质和脂类代谢调节紊乱为特征。胰岛素抵抗是T2DM发病的一个主要因素,有研究显示抵抗素(resistin,RETN)与胰岛素抵抗呈正相关。RETN是脂肪细胞分泌的因子之一,并且在T2DM、肥胖介导的炎症和胰岛素抵抗中起决定性因素。随着研究的不断探索,抵抗素基因的多态性逐渐被认识,充分理解抵抗素基因在T2DM中的多态性表达,有助于更加合理的将其应用于T2DM的诊治及预防中。
Abstract:
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease, one of the major diseases threatening human health in the 21st century, which can lead to severe morbidity and mortality. T2DM is characterized by elevated blood glucose and disorders in the regulation of carbohydrate, protein and lipid metabolism. Insulin resistance is a major factor in the pathogenesis of T2DM, and studies have shown a positive correlation between resistin (RETN), one of the factors secreted by adipocytes and a determinant in T2DM, obesity-mediated inflammation and insulin resistance. With the continuous exploration of research, the polymorphism of the resistance gene is gradually recognized, and a full understanding of the polymorphic expression of the resistance gene in T2DM can help apply it more rationally in the diagnosis, treatment and prevention of T2DM.

参考文献/References

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备注/Memo

备注/Memo:
基金项目:青海省卫生健康委员会指导性计划课题(2020-wjzdx-24)
作者简介:周琳(1996—),女,硕士在读,研究方向:中高海拔地区2型糖尿病合并非酒精性脂肪肝患者与抵抗素基因多态性的相关性研究
通信作者:罗玮,E-mail:1078274834@qq.com
更新日期/Last Update: 2022-07-28