«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《现代预防医学》[ISSN:1003-8507/CN:51-1365/R]

期数:

2022年22期

页码:

4052-4056

栏目:

流行病与统计方法

出版日期:

2022-11-30

文章信息/Info

Title:

Study on prevalence and influencing factors of osteoporosis among Tibetan adults in 6 high-altitude counties of Tibet

作者:

王鹏¹; 熊海¹; 张玉飞¹; 吴翠雪¹; 陈涛²; 邹琴²; 格桑平措²; 何小燕¹

1. 西藏大学医学院，西藏 拉萨 850000；
2. 四川大学华西公共卫生学院/华西第四医院 老年医学/神经内科，四川 成都 610041

Author(s):

WANG Peng*;  XIONG Hai;  ZHANG Yu-fei;  WU Cui-xue;  CHEN Tao;  ZOU Qin;  GESANG Ping-cuo;  HE Xiao-yan

*School of Medicine, Tibet University, Lhasa, Tibet 850000, China

关键词:

骨质疏松; 检出率; 影响因素;  西藏六县

Keywords:

Osteoporosis;  Detection rate;  Influencing factors;  Six counties in Tibet

分类号:

R580

DOI:

10.20043/j.cnki.MPM.202204477

文献标识码:

A

摘要:

目的 了解西藏地区6个高海拔县藏族成年人骨质疏松的患病现状及其影响因素。方法 采用多阶段分层随机抽样，从西藏地区6个高海拔县随机抽取1 309名藏族居民作为研究对象，采用χ2检验和logistic回归方法分析该地区骨质疏松检出率情况及影响因素。结果 西藏地区6个高海拔县成年女性骨质疏松的检出率为3.8％，男性为3.0％；60岁及以上女性骨质疏松的检出率为16.7％，男性为12.8％。Logistic回归分析结果显示：在女性群体中，年龄、从事农牧活动、BMI、绝经与骨质疏松的发生有关。在男性群体中，年龄与骨质疏松的发生有关。结论 西藏地区6个高海拔县60岁及以上男性和女性的骨质疏松的检出率偏低。增龄是该地区藏族成年女性、男性骨质疏松发生的独立危险因素。绝经、BMI偏低是该地区成年女性骨质疏松发生的独立危险因素。从事农牧活动是该地区成年女性骨质疏松发生的保护因素。

Abstract:

Objective To investigate the detection rate and influencing factors of osteoporosis among Tibetan adults in 6 high-altitude counties of Tibet. Methods A total of 1 309 Tibetan residents were randomly selected from 6 high-altitude counties of Tibet by multi-stage stratified random sampling. Chi-square test and Logistic regression were used to analyze the detection rate of osteoporosis and its influencing factors. Results The detection rate of osteoporosis in 6 high-altitude counties of Tibet was 3.8% in females and 3.0% in males, respectively. The detection rate of osteoporosis was 16.7% in females and 12.8% in males over 60 years old, respectively. Logistic regression analysis showed that age, agricultural and pastoral activities, BMI, and menopause were related to the occurrence of osteoporosis in females. In males, age was associated with the development of osteoporosis. Conclusion The detection rate of osteoporosis in males and females over 60 years old in 6 high-altitude counties of Tibet is low. Aging is an independent risk factor for osteoporosis in Tibetan adult females and males. Menopause and low BMI are independent risk factors for osteoporosis in adult females in this area. Engaging in farming and animal husbandry is a protective factor of osteoporosis in adult females in this area.

参考文献/References

[ 1 ] 夏维波，章振林，林华，等．原发性骨质疏松症诊疗指南(2017)[J]．中国骨质疏松杂志，2019，25（3）：281 - 309．Xia WB, Zhang ZL, Lin H, et al. Guidelines for the diagnosis and treatment of primary osteoporosis[J]. Chinese Journal of Osteoporosis, 2019, 25(3): 281 - 309.
[ 2 ] 佚名．老年骨质疏松脊柱内固定术中国专家共识[J]．中华医学杂志，2019，（15）：1138 - 1141．Anonym. Chinese expert consensus on spinal internal fixation for senile osteoporosis[J]. Chinese Medical Journal, 2019, (15): 1138 - 1141.
[ 3 ] 佚名．原发性骨质疏松症诊治指南(2011年)[J]．中华骨质疏松和骨矿盐疾病杂志，2011，4（1）：2 - 17．Anonym. Guidelines for the diagnosis and treatment of primary osteoporosis(2011)[J]. China Osteoporosis and Bone Mineral Salt Diseases, 2011, 4(1): 2 - 17.
[ 4 ] Zhu H, Fang J, Luo X, et al. A survey of bone mineral density of healthy Han adults in China[J]. Osteoporosis International, 2010, 21(5): 765 - 772.
[ 5 ] 佚名．男性骨质疏松症诊疗指南[J]．中华内分泌代谢杂志，2020，36（10）：817 - 827．Anonym. Guidelines for the diagnosis and treatment of osteoporosis in men[J]. Chinese Journal of Endocrinology and Metabolism, 2020, 36(10): 817 - 827.
[ 6 ] Global BC, Di AE, Bhupathiraju S, et al. Body - mass index and all - cause mortality: individual - participant - data meta - analysis of 239 prospective studies in four continents[J]. Lancet, 2016, 388(10046): 776 - 786.
[ 7 ] 刘敏燕，裴育，张颖，等．50岁以上男性不同部位骨密度变化特征及骨质疏松检出率[J]．中华骨质疏松和骨矿盐疾病杂志，2013，6（2）：114 - 120．Liu MY, Pei Y, Zhang Y, et al. Characteristics of bone mineral density and the detection rate of osteoporosis in men over 50 years old[J]. Chinese Journal of Osteoporosis and Bone Mineral Salt Diseases, 2013, 6(2): 114 - 120.
[ 8 ] 陈燕，宋廷霞，何小芬，等．西宁地区1373例正常体检人群骨密度及BMI指数的相关性分析[J]．高原医学杂志，2020，30（1）：39 - 41．Chen Y, Song TX, He XF, et al. Correlation analysis of bone mineral density and body mass index among 1373 normal Normal physical examination subjects in Xining area[J]. Journal of Plateau Medicine, 2020, 30(1): 39 - 41.
[ 9 ] 宗欣，石秀娟，徐艳艳，等．青岛市城阳区老年体检者骨质疏松症流行情况及相关因素调查[J]．应用预防医学，2020，26（3）：227 - 229．Zong X, Dan XJ, Xu YY, et al. Prevalence and related factors of osteoporosis in elderly physical examiners in Chengyang district of Qingdao City[J]. Applied Preventive Medicine, 2020, 26(3): 227 - 229.
[ 10 ] 王欢，马琼，马保安．我国高原地区骨质疏松的研究现况[J]．医学信息，2020，33（23）：34 - 37．Wang H, Ma Q, Ma BA. Research status of osteoporosis in plateau areas of China[J]. Medical Information, 2020, 33(23): 34 - 37.
[ 11 ] 杨秀琳，何烨，马力扬，等．西藏藏族成人体成分与骨量异常的相关性[J]．解剖学报，2017，48（2）：199 - 203．Yang XL, He Y, Ma LY, et al. Correlation between body composition and bone mass abnormalities in Tibetan adults in Tibet[J]. Journal of Anatomia Sinica, 2017, 48(2): 199 - 203.
[ 12 ] 谭赟，张国庆．长期篮球运动对老年人骨代谢的影响[J]．中国老年学杂志，2022，42（6）：1402 - 1405．Tan Y, Zhang GQ. Effects of long - term basketball exercise on bone metabolism in the elderly[J]. Chinese Journal of Gerontology, 2022, 42(6): 1402 - 1405.
[ 13 ] 雷欣东，于慧，龙琼，等．绝经后骨质疏松症发病机制研究进展[J]．中国骨质疏松杂志，2021，27（11）：1681 - 1684．Lei XD, Yu H, Long Q, et al. Research progress on the pathogenesis of postmenopausal osteoporosis[J]. Chinese Journal of Osteoporosis,2021, 27(11): 1681 - 1684.
[ 14 ] Wolski H, Drews K, Bogacz A, et al. The RANKL/RANK/OPG signal trail: significance of genetic polymorphisms in the etiology of postmenopausal osteoporosis[J]. Ginekologia Polska, 2016, 87(5): 347 - 352.
[ 15 ] Britton RA, Irwin R, Quach D, et al. Probiotic L.reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model[J]. Cell Physiol, 2014, 229(11): 1822 - 1830.
[ 16 ] 李丽娟，林静，王凌．肠道微生态影响绝经后骨质疏松症发生发展的研究进展[J]．中国免疫学杂志，2019，35（16）：2032 - 2037．Li LJ, Lin J, Wang L. Effects of intestinal microecology on the development of postmenopausal osteoporosis[J]. Chinese Journal of Immunology, 2019, 35(16): 2032 - 2037.
[ 17 ] Wang X, Chen B, Sun J, et al. Iron - induced oxidative stress stimulates osteoclast differentiation via NF - κB signaling pathway in mouse model[J]. Metabolism, 2018, 83: 167 - 176.
[ 18 ] 邢正，郭兰兰，张靓．骨血管与运动改善骨质疏松的研究进展[J]．中国骨质疏松杂志，2022，28（6）：897 - 903．Xing Z, Guo LL, Zhang J. Research progress of bone vessels and exercise in improving osteoporosis[J]. Chinese Journal of Osteoporosis, 2022, 28(6): 897 - 903.
[ 19 ] 王金玲，黄夏荣，屈萌艰，等．运动训练老年骨质疏松大鼠骨量及骨微结构的变化[J]．中国组织工程研究，2023，27（5）：676 - 682．Wang JL, Huang XR, Qu MJ, et al. Changes of bone mass and microstructure in elderly rats with osteoporosis after exercise training[J]. China Tissue Engineering Research, 2023, 27(5): 676 - 682.
[ 20 ] 吴苗，唐兰，王钰麒，等．探索中老年男性骨量减少和骨质疏松的相关因素[J]．中国骨质疏松杂志，2021，27（9）：1279 - 1282．Wu M, Tang L, Wang YQ, et al. Study on the correlation between bone mass loss and osteoporosis in middle - aged and elderly men[J]. Chinese Journal of Osteoporosis, 2021, 27(9): 1279 - 1282.
[ 21 ] 徐云亮．不同球类运动对大学生上下肢骨密度及其方向性不对称的影响[J]．人类学学报，2021，40（6）：1023 - 1031．Xu YL. Effects of different ball games on upper and lower limb bone mineral density and its directional asymmetry in college students[J]. Acta Anthropologica Sinica, 2021, 40(6): 1023 - 1031.
[ 22 ] 李茂蓉，黄薇，欧小虹，等．绝经后非糖尿病妇女骨质疏松症影响因素的Logistic回归和ROC曲线分析[J]．中国骨质疏松杂志，2016，22（5）：540 - 544．Li MR, Huang W, Ou XH, et al. Logistic regression and ROC curve analysis of risk factors for osteoporosis in postmenopausal non - diabetic women[J]. Chinese Journal of Osteoporosis, 2016, 22(5): 540 - 544.

备注/Memo

备注/Memo:

基金项目：中央财政支持地方高校改革发展专项基金项目（00060585，ZFYJY201902016，ZFYJY201901005）
作者简介：王鹏（1995-），男，硕士在读，研究方向：医学遗传学
通信作者：熊海，E-mail：xhxysq@126.com

常用功能

更新日期/Last Update: 2022-11-30